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Transition metal-catalyzed CH functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides
Tetrahedron Letters  (IF2.415),  Pub Date : 2019-02-26, DOI: 10.1016/j.tetlet.2019.02.031
Bhausaheb N. Patil,Jatin J. Lade,Aniket S. Karpe,B. Pownthurai,Kamlesh S. Vadagaonkar,V. Mohanasrinivasan,Atul C. Chaskar

Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves CH functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approach furnished benzothiadiazine 1,1-dioxide derivatives in good to excellent yields. Broad substrate scope, inexpensive catalyst and high product yields are notable features of this protocol.