Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)–H Bonds Organic Letters (IF6.072), Pub Date : 2022-06-24, DOI: 10.1021/acs.orglett.2c01822 Florence Babawale, Kathiravan Murugesan, Rok Narobe, Burkhard König
The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation–radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp3)–H bonds has not been fully explored. Herein, we report a photocatalytic protocol for the synthesis of unnatural α-amino esters employing abundant alkanes and imines retaining full atom economy. When this method is applied, several amino acid derivatives are synthesized in moderate to good yields.