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Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)–H Bonds
Organic Letters  (IF6.072),  Pub Date : 2022-06-24, DOI: 10.1021/acs.orglett.2c01822
Florence Babawale, Kathiravan Murugesan, Rok Narobe, Burkhard König

The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation–radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp3)–H bonds has not been fully explored. Herein, we report a photocatalytic protocol for the synthesis of unnatural α-amino esters employing abundant alkanes and imines retaining full atom economy. When this method is applied, several amino acid derivatives are synthesized in moderate to good yields.