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Palladium-Catalyzed Regioselective [5 + 1] Annulation of Vinyl Aziridines/Epoxides with ClCF2COONa
Organic Letters  (IF6.072),  Pub Date : 2022-06-22, DOI: 10.1021/acs.orglett.2c01739
Dandan Zuo, Tao Zhang, Jingjing Zhao, Wen Luo, Chaojie Wang, Pan Li

Palladium-catalyzed regioselective [5 + 1] annulation reactions of vinyl aziridines/epoxides with ClCF2COONa have been developed. Significantly, vinyl aziridines/epoxides act as heteroatom-containing five-atom synthons, and commercially available and cheap ClCF2COONa acts as the source of carbonyl serving as a difluorocarbene precursor. This protocol provides an efficient and practical method for the synthesis of δ-lactams and δ-lactones in good yields.