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General anesthesia and the cortical stranglehold on consciousness
Neuron  (IF18.688),  Pub Date : 2022-06-15, DOI: 10.1016/j.neuron.2022.05.014
Dinesh Pal, George A. Mashour

In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these findings for the mechanism of consciousness and anesthetic-induced unconsciousness.