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PRC2 shields the potency of human stem cells
Nature Cell Biology  (IF28.213),  Pub Date : 2022-06-13, DOI: 10.1038/s41556-022-00937-5
Sergi Aranda, Livia Condemi, Luciano Di Croce

Human naive pluripotent stem cells are generally believed to possess an unrestricted capacity to differentiate into both embryonic and extraembryonic lineages. However, two new studies now uncover a role for the Polycomb repressive complex 2 (PRC2) as a lineage gatekeeper that shields the potency of these cells.