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Forced entry into the nucleus
Nature Cell Biology  (IF28.213),  Pub Date : 2022-06-09, DOI: 10.1038/s41556-022-00939-3
Stefan Petrovic, André Hoelz

The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.