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A chosen STING with a PERKy trail
Nature Cell Biology  (IF28.213),  Pub Date : 2022-05-02, DOI: 10.1038/s41556-022-00905-z
Younis Hazari, Claudio Hetz

Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to cellular senescence and organ fibrosis.