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Mitochondrial shape alteration by metabolites
Nature Cell Biology  (IF28.213),  Pub Date : 2022-04-13, DOI: 10.1038/s41556-022-00889-w
Till Klecker, Benedikt Westermann

Organic acidurias are inherited disorders that can severely affect mitochondria. A study in Caenorhabditis elegans suggests that binding of a toxic metabolite to a factor crucial for mitochondrial structure may contribute to disease mechanisms.