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Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth
JAMA Psychiatry  (IF21.596),  Pub Date : 2022-02-01, DOI: 10.1001/jamapsychiatry.2021.3700
Boris Birmaher, Danella Hafeman, John Merranko, Alyson Zwicker, Benjamin Goldstein, Tina Goldstein, David Axelson, Kelly Monk, Mary Beth Hickey, Dara Sakolsky, Satish Iyengar, Rasim Diler, Vishwajit Nimgaonkar, Rudolf Uher

This case-control study evaluated whether parents with bipolar disorder and their offspring had specifically increased bipolar disorder polygenic risk scores compared with polygenic risk scores for depression, schizophrenia, and attention-deficit/hyperactivity disorder.