Find Paper, Faster
Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Antihistamines for cancer immunotherapy: More than just treating allergies
Cancer Cell  (IF31.743),  Pub Date : 2021-12-02, DOI: 10.1016/j.ccell.2021.11.007
Song Chen, Andrew D. Luster

In this issue of Cancer Cell, Li et al. show that histamine released in allergic reactions and from tumor cells attenuates immunotherapy response. Histamine H1-receptor (H1R) signaling induces an M2-like phenotype in tumor-associated macrophages and increases VISTA expression, suppressing CD8+ T cell function. Antihistamines reverse these effects and improve the efficacy of immunotherapy.