Interphase mass transfer and associated chemical reactions in biphasic liquid flow can be enhanced by tuning the phase distribution in the flow reactor. In reduced dimensions, a balance between surface, inertial and viscous forces results in either segmented flow where dispersed phase is distributed as plugs / droplets in the carrier phase, or thread flow where dispersed phase flows as a continuous thread through an annular film of the carrier phase. Our extensive experiments in up, down and horizontal co-flows of a liquid-liquid mixture through a glass conduit of 2.38 mm diameter reveal a subtle role of gravity in the mesodomain. We note plug generation by gravity assisted squeezing mechanism in upflow and observe squeezing, dripping and jetting mechanisms in the same device by a mere change in conduit orientation. While upflow promotes monodispersed plug generation, downflow is more conductive for thread flow and droplets rather than plugs are formed in horizontal flow. An in-depth investigation of plug generation cycle over a wide range of flow velocities suggests polydispersity to increase as thread pinch off occurs further from the T-entry. The increase in dispersed phase hold-up with flow rate ratio is steeper for segmented flow than thread flow.