Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
New Heights for ProTides? Journal of Medicinal Chemistry (IF7.446), Pub Date : 2021-11-16, DOI: 10.1021/acs.jmedchem.1c01908 Carlo Ballatore
In this issue of the Journal of Medicinal Chemistry, Janeba et al. found that the in vitro antiviral activity and selectivity index of the aryloxy phosphoramidate (ProTide) prodrug of the acyclic nucleoside phosphonate tenofovir (tenofovir alafenamide) can be dramatically improved by replacing the aryloxy pro-moiety with an appropriate tyrosine derivative. This Viewpoint highlights the possible impact and ramifications that these findings may have in the development of new ProTides.