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Capitalizing on the messenger: Intra-tumoral delivery of RNA with a systemic effect
Cancer Cell  (IF31.743),  Pub Date : 2021-11-08, DOI: 10.1016/j.ccell.2021.10.004
Patrick A. Ott

As reported recently in Science Translational Medicine, intra-tumoral administration of mRNAs that encode four cytokines formulated in saline mediates regression of injected and distant murine tumors. The anti-tumor effect, which is also seen in the anti-PD-1-resistant setting and enhanced by checkpoint blockade, is mediated by tumor-specific T cells and natural killer cells.