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Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill
Cancer Cell  (IF31.743),  Pub Date : 2021-11-04, DOI: 10.1016/j.ccell.2021.10.011
Florian Uhlitz, Dmitriy Zamarin

High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)+ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.