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Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells
Cancer Cell  (IF31.743),  Pub Date : 2021-11-04, DOI: 10.1016/j.ccell.2021.10.013
Kevin Sek, Cheok Weng Chan, Paul A. Beavis, Phillip K. Darcy

In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFNα/β production.