Stretchable, skin-conformal, and self-powered wearable pressure sensors have garnered significant attention for use in human joint bending motion monitoring. Here, a piezo-triboelectric pressure sensor (P-TPS) based on triboelectric nanogenerator and piezoelectric nanogenerator is demonstrated. The P-TPS can generate an enhanced electrical output by coupling the dual-mode triboelectrification and piezoelectric effect. The P-TPS shows high sensitivity (voltage = 0.3 V/kPa; current = 4.3 nA/kPa; pressure range = 0–200 kPa), high linearity, and good stability. Furthermore, it demonstrates a wide measurement range (0–800 kPa), table frequency response, and fast response time. Additionally, all components of the P-TPS are fabricated using flexible and stretchable materials, affording satisfactory stretchability and excellent skin conformality. Owing to their ability to self-power, they can be attached to the outside of joints to monitor human joint bending movements in real time. Hence, this study provides a novel method of using a stretchable and skin-conformal piezo-triboelectric nanogenerator with high electrical performance as a self-powered pressure sensor, which offers significant potential in personalized recognition, medical research, and human machine interface.