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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Efficacy of Hibiscus Sabdariffa on Reducing Blood Pressure in Patients with Mild to Moderate Hypertension: A Systematic Review and Meta-Analysis of published randomized controlled trials.
Journal of Cardiovascular Pharmacology  (IF3.105),  Pub Date : 2021-10-20, DOI: 10.1097/fjc.0000000000001161
Mohamed Abdelmonem, Mahmoud Ahmed Ebada, Sherein Diab, Mariam Mohamed Ahmed, Mohamed Sayed Zaazouee, Tarek Mohamed Essa, Zainab Salah ElBaz, Hazem S Ghaith, Walid Shaban Abdella, Mohamed Ebada, Ahmed Negida

We aimed to assess the efficacy of hibiscus sabdariffa in patients with mild to moderate hypertension or metabolic syndrome (MetS) by comparing it against placebo, antihypertensive drugs, or other herbal products.Four databases were searched for randomized clinical trials (RCTs) examining the efficacy of hibiscus sabdariffa in patients with mild to moderate hypertension or hypertension associated with MetS. Data on the change in systolic blood pressure (SBP) and diastolic blood pressure (DBP) were extracted and analyzed using Review Manager Version 5.3.A total of 13 RCTs (1205 participants) were analyzed. Hibiscus sabdariffa significantly reduced both SBP and DBP compared to placebo (MD -6.67, P=0.004 and -4.35 mmHg, P=0.02). Subgroup analysis showed that change in SBP and DBP was statistically significant in patients with only hypertension while not significant in patients with hypertension associated with MetS. When hibiscus sabdariffa was compared to active controls (antihypertensive drugs or other herbals), the change in SBP and DBP was not statistically significant (all P>0.05).Hibiscus sabdariffa is effective in reducing the SBP and DBP in patients with mild to moderate hypertension but was neither effective in those with MetS nor superior to antihypertensive drugs. Further RCTs are required to determine the long-term efficacy of hibiscus sabdariffa and to describe patients who would benefit most from this treatment.