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Is muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations
Journal of Cachexia, Sarcopenia and Muscle  (IF12.91),  Pub Date : 2021-10-20, DOI: 10.1002/jcsm.12766
Claire Laurens, Franziska Grundler, Anthony Damiot, Isabelle Chery, Anne-Laure Le Maho, Alexandre Zahariev, Yvon Le Maho, Audrey Bergouignan, Guillemette Gauquelin-Koch, Chantal Simon, Stéphane Blanc, Françoise Wilhelmi de Toledo

Fasting is attracting an increasing interest as a potential strategy for managing diseases, including metabolic disorders and complementary cancer therapy. Despite concerns of clinicians regarding protein catabolism and muscle loss, evidence-based clinical data in response to long-term fasting in healthy humans are scarce. The objective of this study was to measure clinical constants, metabolic, and muscular response in healthy men during and after a 10 day fast combined with a physical activity programme.