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Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease
Journal of Cachexia, Sarcopenia and Muscle  (IF12.91),  Pub Date : 2021-10-17, DOI: 10.1002/jcsm.12830
Tsukasa Nagase, Chihiro Tohda

Alzheimer's disease (AD) is an unmet medical need worldwide, and physical inactivity is a risk factor for AD. Performing physical exercise is difficult at old age, and thus, decline in physical movement may be a cause of age-associated lowering of the brain function. This study aimed to elucidate the molecular mechanism and onset of the skeletal muscle atrophy-induced acceleration of AD.