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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes
ACS Catalysis  (IF13.084),  Pub Date : 2021-10-15, DOI: 10.1021/acscatal.1c04183
Xiangqing Jia, Ziyan Zhang, Vladimir Gevorgyan

A mild visible-light-induced Pd-catalyzed one-pot three-component alkyl-carbamoylation and cyanation of alkenes was developed. This general transformation, which proceeds via the in situ formation of a reactive ketenimine intermediate, allows for a rapid construction of a broad range of valuable amides and nitriles from readily available alkenes, alkyl iodides, and isocyanides. An efficient synthesis of tetrazole and amidine via this approach was also demonstrated.