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Acute Chagas Disease Manifesting as Orbital Cellulitis, Texas, USA
Emerging Infectious Diseases  (IF6.883),  Pub Date : 2021-10-13, DOI: 10.3201/eid2711.203698
F. Parker Hudson, Natalie Homer, Aliza Epstein, Kristin Mondy

We report a case of acute, vectorborne Chagas disease, acquired locally in central Texas, USA, manifesting as Romaña’s sign, which was initially mistaken for orbital cellulitis. After the infection failed to respond to antibiotics, DNA-based next generation sequencing on plasma yielded high levels of Trypanasoma cruzi; results were confirmed by PCR.