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Goodbye PAM: Phage λ’s Red recombination system cripples PAMs and helps dodge CRISPR attacks
Cell Host & Microbe  (IF21.023),  Pub Date : 2021-10-13, DOI: 10.1016/j.chom.2021.09.011
Khang Ho, Rasika M. Harshey

Ever wondered how the phage λ Red recombination system resembles the Red Queen? Hossain et al. (2021) provide an answer in this issue of Cell Host & Microbe. They show that Red debilitates PAM sequences by mutagenic repair of CRISPR-targeted DNA breaks in infecting λ, thus shaping the phage-CRISPR arms race.