Find Paper, Faster
Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
The glial framework reveals white-matter fiber architecture in human and primate brains
Science  (IF47.728),  Pub Date : 2021-10-07, DOI: 10.1126/science.abj7960
Roey Schurr, Aviv A. Mezer

Uncovering the architecture of white-matter axons is fundamental to the study of brain networks. We developed a method for quantifying axonal orientations at ~15 micron resolution. This method is based on the common Nissl staining of postmortem histological slices. Nissl staining reveals the spatial organization of glial cells along axons. Using structure tensor analysis, we leveraged this patterned organization to uncover the local axonal orientation. We used Nissl-based structure-tensor analysis to extract fine details of axonal architecture and demonstrated its applicability in multiple datasets of humans and non-human primates. Nissl-based structure tensor analysis can be used to compare fine-grained features of axonal architecture across species, and is widely applicable to existing datasets.