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Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients
Journal of Cachexia, Sarcopenia and Muscle  (IF12.91),  Pub Date : 2021-10-05, DOI: 10.1002/jcsm.12804
Jorne Ubachs, Janine Ziemons, Zita Soons, Romy Aarnoutse, David P.J. van Dijk, John Penders, Ardy van Helvoort, Marjolein L. Smidt, Roy F.P.M. Kruitwagen, Lieke Baade-Corpelijn, Steven W.M. Olde Damink, Sander S. Rensen

Cancer cachexia is characterized by a negative energy balance, muscle and adipose tissue wasting, insulin resistance, and systemic inflammation. Because of its strong negative impact on prognosis and its multifactorial nature that is still not fully understood, cachexia remains an important challenge in the field of cancer treatment. Recent animal studies indicate that the gut microbiota is involved in the pathogenesis and manifestation of cancer cachexia, but human data are lacking. The present study investigates gut microbiota composition, short-chain fatty acids (SCFA), and inflammatory parameters in human cancer cachexia.