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The Immune Response in Multiple Sclerosis.
Annual Review of Pathology: Mechanisms of Disease  (IF23.472),  Pub Date : 2021-10-04, DOI: 10.1146/annurev-pathol-052920-040318
Sofía Rodríguez Murúa,Mauricio F Farez,Francisco J Quintana

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells, triggering demyelination, axonal damage, and neurodegeneration. Although the exact causes of MS are not fully understood, genetic and environmental factors are thought to control MS onset and progression. In this article, we review the main immunological mechanisms involved in MS pathogenesis. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 17 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.