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Dissecting bulk transcriptomes of diffuse large B cell lymphoma
Cancer Cell  (IF31.743),  Pub Date : 2021-09-30, DOI: 10.1016/j.ccell.2021.09.006
Dylan R. McNally, Olivier Elemento, Ari Melnick

Diffuse large B cell lymphoma (DLBCL) is a markedly phenotypically heterogenous disease, frequently assessed using bulk genomic techniques that blur the intrinsic heterogeneity of each tumor. In this issue of Cancer Cell, Steen et al. have utilized a computational framework called EcoTyper to skillfully dissect bulk transcriptomic tumor profiles into different cell type components in an unsupervised manner.