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Transition-metal-free intermolecular chloro-difluoromethylthiolation of Alkenes and alkynes
European Journal of Organic Chemistry  (IF3.021),  Pub Date : 2021-09-22, DOI: 10.1002/ejoc.202101109
Wan-Qiang Yuan, Li-Yun Guo, Yu-Tao Liu, Qing Li, Jie Shi, Fei Pan

A general and convenient method for the direct transition-metal-free intermolecular chloro- difluoromethylthiolation of a variety of unactivated alkenes and alkynes has been described. This methodology exhibits good functional group tolerance and operationally simple. Mechanistic studies indicated that this is the electrophilic substitution mechanism, and the strong electrophilic difluoromethylthiolating reagent HCF 2 SCl was generated in situ under the standard reaction conditions. The developed protocol fulfills the requirements of sustainable and green chemistry.