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Gepotidacin Pharmacokinetics-Pharmacodynamics Against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems
Antimicrobial Agents and Chemotherapy  (IF5.191),  Pub Date : 2021-09-20, DOI: 10.1128/aac.00122-21
Brian D. VanScoy, Elizabeth A. Lakota, Haley Conde, Steven Fikes, Sujata M. Bhavnani, Philippa.B. Elefante, Nicole E. Scangarella-Oman, Paul G. Ambrose

Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the following:...