Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Gepotidacin Pharmacokinetics-Pharmacodynamics Against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems Antimicrobial Agents and Chemotherapy (IF5.191), Pub Date : 2021-09-20, DOI: 10.1128/aac.00122-21 Brian D. VanScoy, Elizabeth A. Lakota, Haley Conde, Steven Fikes, Sujata M. Bhavnani, Philippa.B. Elefante, Nicole E. Scangarella-Oman, Paul G. Ambrose
Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits
bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the following:...