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Cover Feature: Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives (Eur. J. Org. Chem. 36/2021)
European Journal of Organic Chemistry  (IF3.021),  Pub Date : 2021-09-13, DOI: 10.1002/ejoc.202101108
Kristaps Leškovskis, Jānis Miķelis Zaķis, Irina Novosjolova, Māris Turks

The Cover Feature shows the essence of purine ring opening pathways. Electrophilic activation of purine by pulling its electron density from N(1) or N(7) and subsequent nucleophile attack ensures the ring-opening of the pyrimidine or imidazole part of the parent heterocycle. The obtained products can be used as such or submitted to further rearrangements and cyclizations. This methodology is a useful addition to the synthetic toolbox of heterocyclic chemistry. More information can be found in the Review by I. Novosjolova, M. Turks et al.