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The antimicrobial peptide MK58911-NH2 acts on planktonic, biofilm and intramacrophage cells of Cryptococcus neoformans
Antimicrobial Agents and Chemotherapy  (IF5.191),  Pub Date : 2021-09-13, DOI: 10.1128/aac.00904-21
Junya de Lacorte Singulani, Lariane Teodoro Oliveira, Marina Dorisse Ramos, Nathália Ferreira Fregonezi, Paulo César Gomes, Mariana Cristina Galeane, Mario Sergio Palma, Ana Marisa Fusco Almeida, Maria José Soares Mendes Giannini

Cryptococcosis is associated with high rates of morbidity and mortality, especially in AIDS patients. Its treatment is carried out by combining amphotericin B and azoles or flucytosine, which cause unavoidable toxicity issues to the host. Thus, the ...