Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Species-specific differences in C-5 sterol desaturase function influence the outcome of azole antifungal exposure. Antimicrobial Agents and Chemotherapy (IF5.191), Pub Date : 2021-09-13, DOI: 10.1128/aac.01044-21 Arturo Luna-Tapia, Josie E. Parker, Steven L. Kelly, Glen E. Palmer
The azole antifungals inhibit sterol 14α-demethylase (S14DM), leading to depletion
of cellular ergosterol and the synthesis of an aberrant sterol-diol that disrupts
membrane function. In Candida albicans, sterol diol production is catalyzed by the C-5 ...