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Efficient Inhibition of Hepatitis B Virus Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors During Infection
Antimicrobial Agents and Chemotherapy  (IF5.191),  Pub Date : 2021-09-13, DOI: 10.1128/aac.01460-21
Ranjit Chauhan, Qilan Li, Molly E. Woodson, Makafui Gasonoo, Marvin J. Meyers, John E. Tavis

The Hepatitis B Virus (HBV) ribonuclease H (RNase H) is an attractive but unexploited drug target. Here, we addressed three limitations to the current state of RNase H inhibitor development: i) Efficacy has been assessed only in transfected cell lines; ii)...