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Restoring order at the cell cycle border: Co-targeting CDK4/6 and CDK2
Cancer Cell  (IF31.743),  Pub Date : 2021-09-09, DOI: 10.1016/j.ccell.2021.08.007
Rinath Jeselsohn, Rachel Schiff, Albert Grinshpun

Overcoming resistance to CDK4/6 inhibitors is a major clinical challenge. In this issue of Cancer Cell, Freeman-Cook et al. study mechanisms of resistance to CDK4/6 inhibitors by employing a CRISPRa screen. They identify the cyclin E-CDK2 axis and Myc signaling as key pathways of resistance and develop PF-06873600, a selective CDK2/4/6 inhibitor.