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Age and sex-related variability in the presentation of generalized anxiety and depression symptoms
Depression and Anxiety  (IF6.505),  Pub Date : 2021-09-08, DOI: 10.1002/da.23213
Katherine N. Thompson, Christopher Hübel, Rosa Cheesman, Brett N. Adey, Chérie Armour, Molly R. Davies, Matthew Hotopf, Ian R. Jones, Gursharan Kalsi, Andrew M. McIntosh, Dina Monssen, Alicia J. Peel, Henry C. Rogers, Megan Skelton, Daniel J. Smith, James T. R. Walters, Gerome Breen, Thalia C. Eley

Generalized anxiety and depression are extremely prevalent and debilitating. There is evidence for age and sex variability in symptoms of depression, but despite comorbidity it is unclear whether this extends to anxiety symptomatology. Studies using questionnaire sum scores typically fail to address this phenotypic complexity.