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Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives
Chemistry of Heterocyclic Compounds  (IF1.277),  Pub Date : 2021-09-08, DOI: 10.1007/s10593-021-02987-3
Shkineva, Tatyana K., Vatsadze, Irina A., Khoranyan, Tigran E., Lipilin, Dmitry L., Pivkina, Alla N., Dalinger, Igor L.

A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl-O-acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic substitution reactions in the obtained nitro derivatives.