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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
A new small-molecule compound, Q308, silences latent HIV-1 provirus by suppressing Tat- and FACT-mediated transcription
Antimicrobial Agents and Chemotherapy  (IF5.191),  Pub Date : 2021-09-07, DOI: 10.1128/aac.00470-21
Chen-liang Zhou, Yi-fan Huang, Yi-bin Li, Tai-zhen Liang, Teng-yi Zheng, Pei Chen, Zi-yao Wu, Fang-yuan Lai, Shu-wen Liu, Bao-min Xi, Lin Li

Eliminating the latent HIV reservoir remains a difficult problem for creating an HIV functional cure or achieving remission. The “block-and-lock” strategy aims to steadily suppress transcription of the viral reservoir and lock the HIV promoter in deep ...