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When homologous sequences meet structural decoys: Accurate contact prediction by tFold in CASP14—(tFold for CASP14 contact prediction)
Proteins: Structure, Function, and Bioinformatics  (IF3.756),  Pub Date : 2021-09-02, DOI: 10.1002/prot.26232
Tao Shen, Jiaxiang Wu, Haidong Lan, Liangzhen Zheng, Jianguo Pei, Sheng Wang, Wei Liu, Junzhou Huang

In this paper, we report our tFold framework's performance on the inter-residue contact prediction task in the 14th Critical Assessment of protein Structure Prediction (CASP14). Our tFold framework seamlessly combines both homologous sequences and structural decoys under an ultra-deep network architecture. Squeeze-excitation and axial attention mechanisms are employed to effectively capture inter-residue interactions. In CASP14, our best predictor achieves 41.78% in the averaged top-L precision for long-range contacts for all the 22 free-modeling (FM) targets, and ranked 1st among all the 60 participating teams. The tFold web server is now freely available at: https://drug.ai.tencent.com/console/en/tfold.