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Near Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/CRF07_BC) Among MSM in Shijiazhuang City, Hebei Province, China
AIDS Research and Human Retroviruses  (IF2.205),  Pub Date : 2021-08-31, DOI: 10.1089/aid.2021.0100
Mr. Leilei Han, Dr. Hanping Li, Dr. Lijing Wang, Dr. Lei Jia, Dr. Jingwan Han, Mrs. Tianyi Li, Dr. Xiaolin Wang, Mr. Yongjian Liu, Prof. Jingyun Li, Dr. Jianhua Lu, Dr. Xiaojing Qu, Dr. Xuhui He, Dr. Haichun Liu, Dr. Lin Li, Prof. Erhei Dai

URFs are more likely developed among HIV-1 infections through MSM because of multiple subtypes co-circulation. In this study, two novel URFs deriving from two HIV-positive subjects (HB010014, HB010063) were identified in Shijiazhuang, Hebei province, China, and two sequences formed a distinct monophyletic cluster. The further recombination analysis showed that of two new URFs were consisted of CRF01_AE and CRF07_BC. The subregion phylogenetic analysis indicated that CRF01_AE segments were traced back to cluster 4 of CRF01_AE strains, which were prevalent among HIV-1 infections through MSM in China. New URFs being developing gradually and spreading released that more and more novel recombinant strains of HIV-1 could be developed, which means that the past prevention strategies need to be adjusted.