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Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive-compulsive disorder: Results from two pilot studies
Depression and Anxiety  (IF6.505),  Pub Date : 2021-08-31, DOI: 10.1002/da.23212
Thomas G. Adams, Josh M. Cisler, Benjamin Kelmendi, Jamilah R. George, Stephen A. Kichuk, Christopher L. Averill, Alan Anticevic, Chadi G. Abdallah, Christopher Pittenger

Exposed-based psychotherapy is a mainstay of treatment for obsessive-compulsive disorder (OCD) and anxious psychopathology. The medial prefrontal cortex (mPFC) and the default mode network (DMN), which is anchored by the mPFC, promote safety learning. Neuromodulation targeting the mPFC might augment therapeutic safety learning and enhance response to exposure-based therapies.