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Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
Archives of Virology  (IF2.574),  Pub Date : 2021-08-27, DOI: 10.1007/s00705-021-05208-6
Abril Paulina Rodríguez-Maldonado,Joel Armando Vázquez-Pérez,Alberto Cedro-Tanda,Blanca Taboada,Celia Boukadida,Claudia Wong-Arámbula,Tatiana Ernestina Nuñez-García,Natividad Cruz-Ortiz,Gisela Barrera-Badillo,Lucía Hernández-Rivas,Irma López-Martínez,Alfredo Mendoza-Vargas,Juan Pablo Reyes-Grajeda,Nicolas Alcaraz,Fernando Peñaloza-Figueroa,Dulibeth Gonzalez-Barrera,Daniel Rangel-DeLeon,Luis Alonso Herrera-Montalvo,Fidencio Mejía-Nepomuceno,Alejandra Hernández-Terán,Mario Mújica-Sánchez,Eduardo Becerril-Vargas,José Arturo Martínez-Orozco,Rogelio Pérez-Padilla,Jorge Salas-Hernández,Alejandro Sanchez-Flores,Pavel Isa,Margarita Matías-Florentino,Santiago Ávila-Ríos,José Esteban Muñoz-Medina,Concepción Grajales-Muñiz,Angel Gustavo Salas-Lais,Andrea Santos Coy-Arechavaleta,Alfredo Hidalgo-Miranda,Carlos F Arias,José Ernesto Ramírez-González

SARS-CoV-2 variants emerged in late 2020, and at least three variants of concern (B.1.1.7, B.1.351, and P1) have been reported by WHO. These variants have several substitutions in the spike protein that affect receptor binding; they exhibit increased transmissibility and may be associated with reduced vaccine effectiveness. In the present work, we report the identification of a potential variant of interest, harboring the mutations T478K, P681H, and T732A in the spike protein, within the newly named lineage B.1.1.519, that rapidly outcompeted the preexisting variants in Mexico and has been the dominant virus in the country during the first trimester of 2021.