With the continuous development of human society and urban construction, exploring sustainable power sources of monitor and protection systems for city’s infrastructure is becoming more and more urgent. Scavenging ambient fluid flow energy to efficiently and conveniently power electric devices has potential applications for pipeline systems, especially in remote areas. Here, a multi-cylinder-based hybridized electromagnetic-triboelectric nanogenerator (MCNG) is reported to harvest two types of fluid energy at the same time to double the working frequency of the hybrid NG. The introduction of Nylon film effectively improved the durability and output performance. And the structure to transmit external mechanical through magnetic coupling is easy to packaging and assembly, which provides a stable inner environment. Moreover, the hybrid nanogenerator was demonstrated to effectively harvest energy from wind and water flow to power 1075 LEDs and a temperature sensor. Furthermore, a self-powered wireless pipeline leakage monitoring system and a self-powered cathodic protection system based on the MCNG are developed and illustrated. This work provides a prospective strategy for hybrid nanogenerator to improve working frequency and output stability for practical applications.