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ZnO Nanoparticles Embedded on a Reduced Graphene Oxide Nanosheet (ZnO−NPs@r-GO) as a Proficient Heterogeneous Catalyst for a One-Pot A3-Coupling Reaction
European Journal of Inorganic Chemistry  (IF2.524),  Pub Date : 2021-08-18, DOI: 10.1002/ejic.202100368
Dikin Patel, Chetan K. Modi, Prafulla K. Jha, Himanshu Srivastava, Sanjeev R. Kane

This study reports a simple and facile route for the synthesis of ZnO nanoparticles (ZnO−NPs) decorated on reduced graphene oxide nanosheet (ZnO−NPs@r-GO) as a heterogeneous catalyst and tested over multicomponent one-pot A3-coupling reaction. The reduction of graphene oxide with the anchoring of ZnO−NPs on the r-GO nanosheet was observed through the X-ray diffraction patterns, Raman, FTIR, and XPS results of the ZnO−NPs@r-GO sample. ZnO−NPs (average particle size of 3.4±1.5 nm) with uniform size distribution over r-GO nanosheet were substantiated through HRTEM analysis. Impressively, ZnO−NPs@r-GO significantly used for A3-coupling reaction with different aromatic aldehydes, active methylene compounds, and urea and under the optimized reaction conditions gave exceptional activity to produce synthetically valuable 3,4-dihydropyrimidinones products (possessing diverse therapeutic and pharmacological properties) i. e. 97 % isolated yield of the product. In addition, excellent reusability up to 4 repeated cycles are the key advantages of the present catalyst used for this multicomponent A3-coupling reaction.