Chronic illness is always a challenge for the patient and their support system. End-Stage Renal Disease is a chronic health condition in which the patient and family have to undergo many physical, psychological, and social issues. Psychosocial interventions are found to be effective in helping the affected patient and family to cope with illness-related psychosocial issues. This scoping review aims to identify psychosocial interventions for persons with End-stage renal disease to manage psychosocial issues related to the illness. The scoping review found 25 studies on psychosocial interventions for persons with End-Stage Renal Disease. The majority of the studies (17) were randomized controlled trials. Most of the studies were conducted in the USA and Taiwan. Most of the studies were published between 2014–2019. Psychosocial interventions mainly focussed on depression, quality of life, and fluid restriction adherence. Psychosocial intervention studies were found to be effective in attaining desired outcomes.