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An updated classification and mechanistic insights into ligand binding of the substrate-binding proteins
FEBS Letters  (IF4.124),  Pub Date : 2021-08-11, DOI: 10.1002/1873-3468.14174
Monika Chandravanshi, Sisir Kant Tripathi, Shankar Prasad Kanaujia

Substrate-binding proteins (SBPs) mediate ligand translocation and have been classified into seven clusters (A-G). Although the substrate specificities of these clusters are known to some extent, their ligand-binding mechanism(s) remain(s) incompletely understood. In this study, the list of SBPs belonging to different clusters was updated (764 SBPs) compared to the previously reported study (504 SBPs). Furthermore, a new cluster referred to as cluster H was identified. Results reveal that SBPs follow different ligand-binding mechanisms. Intriguingly, the majority of the SBPs follow the ‘one domain movement’ rather than the well-known ‘Venus Fly-trap’ mechanism. Moreover, SBPs of a few clusters display subdomain conformational movement rather than the complete movement of the N- and C-terminal domains.