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Prediction of clinically important acquired cardiac disease without an echocardiogram in large breed dogs using a combination of clinical, radiographic and electrocardiographic variables
Journal of Veterinary Cardiology  (IF1.701),  Pub Date : 2021-08-03, DOI: 10.1016/j.jvc.2021.07.003
S. Wesselowski, S.G. Gordon, N. Meddaugh, A.B. Saunders, J. Häggström, K. Cusack, B.W. Janacek, D.J. Matthews

Introduction

Large breed (LB) dogs develop dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD). Echocardiography is required for definitive diagnosis but not always available. Our objective was to assess clinical utility of thoracic radiographs alone, and in combination with physical examination and electrocardiography findings, for prediction of clinically important DCM or MMVD in LB dogs.

Animals

Four hundred fifty-five client owned dogs ≥20 kg with concurrent thoracic radiographs and echocardiogram.

Materials and Methods

Medical records were reviewed and stored thoracic radiographs and echocardiographic images were measured to classify dogs as normal heart size (NHS), preclinical DCM, clinical DCM, preclinical MMVD (with cardiomegaly), clinical MMVD, or equivocal. Dogs with preclinical MMVD without cardiomegaly were classified as NHS. Vertebral heart size (VHS) and vertebral left atrial size (VLAS) were measured. Receiver operating characteristic curves and prediction models were derived.

Results

Prevalence of MMVD (39.3%) was higher than prevalence of DCM (24.8%), though most MMVD dogs (67.0%) lacked cardiomegaly and were classified as NHS for analysis. Area under the curve (AUC) for VHS to discriminate between NHS versus clinical DCM/MMVD or versus preclinical DCM/MMVD was 0.861 and 0.712, respectively, while for VLAS it was 0.891 and 0.722, respectively. Predictive models incorporating physical examination and electrocardiography findings in addition to VHS/VLAS increased AUC to 0.978 (NHS vs clinical DCM/MMVD) and 0.829 (NHS vs preclinical DCM/MMVD).

Conclusions

Thoracic radiographs were useful for predicting clinically important DCM or MMVD in LB dogs, with improved discriminatory ability when physical examination abnormalities and arrhythmias were accounted for.