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Metastable epialleles are stable in their instability
Nature Genetics  (IF38.33),  Pub Date : 2021-07-29, DOI: 10.1038/s41588-021-00907-x
Bourc’his, Deborah

Metastable epialleles refer to loci with variable methylation states among individuals without underlying genetic differences. Although these loci have generally been assumed to be vulnerable to environmental influence, a new study reports their remarkable metastable epigenetic robustness toward a range of physiological, chemical and dietary disruptions in mammals.