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Detouring adrenergic stimulation to induce adipose thermogenesis
Nature Reviews Endocrinology  (IF43.33),  Pub Date : 2021-07-29, DOI: 10.1038/s41574-021-00546-6
Auger, Christopher, Kajimura, Shingo

Harnessing the thermogenic, energy-expending capacity of adipocytes has the potential to combat metabolic disorders. Although β3-adrenergic receptor agonists are the best-known activators of thermogenesis, they carry considerable cardiovascular risks. A new study demonstrates the ability of G protein-coupled receptor 3 to intrinsically drive adipose thermogenesis independent of β3-adrenergic receptor signalling.