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Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related Inflammation and Lipophagy
Hepatology  (IF17.425),  Pub Date : 2021-07-29, DOI: 10.1002/hep.32078
Zechuan Zhang, Zetao Ji, Jianbo He, Yijun Lu, Wenfang Tian, Chang Zheng, Huihui Chen, Quan Zhang, Fei Yang, Minglu Zhang, Yin Yin, Runqiu Jiang, Wen-Ming Chu, Wenjie Zhang, Beicheng Sun

NASH is an advanced stage of liver disease accompanied by lipid accumulation, inflammation, and liver fibrosis. Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) is a member of the “inhibitory” class of α-subunits, and recent studies showed that Gnai2 deficiency is known to cause reduced weight in mice. However, the role of GNAI2 in hepatocytes, particularly in the context of liver inflammation and lipid metabolism, remains to be elucidated. Herein, we aim to ascertain the function of GNAI2 in hepatocytes and its impact on the development of NASH.