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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
In vitro activity of APX2041, a new GWT1-inhibitor and in vivo efficacy of the prodrug APX2104 against Aspergillus fumigatus
Antimicrobial Agents and Chemotherapy  (IF5.191),  Pub Date : 2021-07-26, DOI: 10.1128/aac.00682-21
Shareef K. Shaheen, Praveen R. Juvvadi, John Allen IV, E. Keats Shwab, D. Christopher Cole, Yohannes G. Asfaw, Mili Kapoor, Karen Joy Shaw, William J. Steinbach

Invasive aspergillosis (IA) due to Aspergillus fumigatus is a deadly infection for which new antifungal therapies are needed. Here we demonstrate the efficacy of a Gwt1 inhibitor, APX2041, and its prodrug, APX2104, against A. fumigatus. The wild-type, ...