This study investigates the relationships between psychosocial risk, relationship quality, need for cognition, and quarantine intentions. Empirical data were collected from quarantine hotel guests in Guangzhou. The results show that depression, anxiety, and stress have a negative influence on satisfaction and that trust and intimacy have a positive influence on satisfaction. Trust has a positive influence on intimacy. Trust and intimacy have a positive influence on commitment. Commitment, satisfaction, and intimacy have a positive influence on quarantine intentions. Intimacy mediates the effect of trust on quarantine intentions. Need for cognition moderates the relationship between satisfaction and quarantine intentions. The theoretical and managerial implications of these results are discussed.